Clinical trials

QPI-1002 for Prevention of Delayed Graft Function in Recipients of an Older Donor Kidney Transplant (ReGIFT)

Purpose:

To evaluate the reduction in incidence and severity of delayed graft function with kidney allografts from donors >45 years after brain death (DBD). 

Principal investigator: Adrian Cotterell, MD
Sponsor: Quark Pharmaceuticals Inc.
Trial no.: NCT02610296
Contact Mary Baldecchi (mary.baldecchi@vcuhealth.org)

Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation

Purpose:

Validate the Integrated Diagnostic System in the International Collaborative Microarray (INTERCOM) study.

Principal investigator: Adrian Cotterell, MD
Sponsor: University of Alberta/Transcriptome Sciences Inc.
Trial no.: NCT01299168
Contact: Mary Baldecchi (mary.baldecchi@vcuhealth.org)

A Study to Evaluate a Therapeutic Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seropositive Recipients Undergoing Allogeneic, Hematopoietic Cell Transplant (HCT) (HELIOS)

Purpose: To evaluate the efficacy of ASP0113 compared with a placebo as measured by a primary composite endpoint of overall mortality and CMV end organ disease (EOD) through 1 year post-transplant. Safety of ASP0113 in subjects undergoing allogeneic HCT will also be evaluated.
Principal investigator: Anne King, MD
Sponsor: Astellas Pharma Global Development Inc.
Trial no.: NCT01299168
Contact: Mary Baldecchi (mary.baldecchi@vcuhealth.org)

A Study in Maintenance Kidney Transplant Recipients Following Conversion to Nulojix® (Belatacept)-Based

Purpose: To assess the benefits and risks of changing from Cyclosporine or Tacrolimus to Belatacept between 6-60 months after kidney transplant.
Principal investigator: Gaurav Gupta, MD
Sponsor: Bristol Meyers Squibb
Trial no.: NCT01820572
Contact: Joyce Ruddley (joyce.ruddley@vcuhealth.org)

Hope Act

Purpose: To learn whether organ transplantation from HIV-positive deceased donors is as safe and effective in HIV-positive recipients as transplants from HIV-negative deceased donors.
Principal investigator:  Gaurav Gupta, MD
Sponsor:  VCU Research
Trial no.:  HM20006083
Contact:  Mary Baldecchi (mary.baldecchi@vcuhealth.org)

Hope In Action

Purpose: To learn whether organ transplantation from HIV-positive deceased donors is as safe and effective in HIV-positive recipients as transplants from HIV-negative deceased donors.
Principal investigator: Gaurav Gupta, MD
Sponsor: Johns Hopkins Medical Institutions
Trial no.: Pending
Contact: Mary Baldecchi (mary.baldecchi@vcuhealth.org)